Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 2/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 4/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | PREP | P48147 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20304965 | 1.00 | NR1H2 (0.48) | NR1H2DDB1CRBNKDM4EMAPT | |
| SCHEMBL6717799 | 1.00 | NR1H2 (0.48) | NR1H2DDB1CRBNKDM4EMAPT | |
| SCHEMBL14518857 | 0.86 | NR1H2 (0.40) | NR1H2DDB1CRBNKDM4EMAPT | |
| SCHEMBL19382853 | 0.84 | NR1H2 (0.44) | NR1H2DDB1CRBNKDM4EMAPT | |
| SCHEMBL1344422 | 0.84 | NR1H2 (0.44) | NR1H2DDB1CRBNKDM4EMAPT | |
| SCHEMBL7498390 | 0.82 | DDB1 (0.37) | NR1H2DDB1CRBNKDM4EMAPT | |
| SCHEMBL29187033 | 0.81 | DDB1 (0.36) | NR1H2DDB1CRBNKDM4EMAPT | |
| SCHEMBL29231907 | 0.81 | DDB1 (0.36) | NR1H2DDB1CRBNKDM4EMAPT | |
| SCHEMBL28713661 | 0.81 | DDB1 (0.36) | NR1H2DDB1CRBNKDM4EMAPT | |
| SCHEMBL15971534 | 0.81 | PRKCD (0.32) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117813302-A | Substituted tetrahydrofuran-2-carboxamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2007034445-A2 | NOVEL PIPERAZINE DERIVATIVES AS RENIN INHIBITORS FOR CARDIOVASCULAR EVENTS AND RENAL INSUFFICIENCY | ACTELION PHARMACEUTICALS LTD (CH) | 2007-03-29 | — | — | WO | disclosed |
| WO-2007034445-A2 | NOVEL PIPERAZINE DERIVATIVES AS RENIN INHIBITORS FOR CARDIOVASCULAR EVENTS AND RENAL INSUFFICIENCY | ACTELION PHARMACEUTICALS LTD (CH) | 2007-03-29 | — | — | WO | disclosed |