Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | KLK7 | P49862 | 2/20 | 0.48 |
| ▸ | KLK5 | Q9Y337 | 2/20 | 0.48 |
| ▸ | CTSK | P43235 | 1/20 | 0.48 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.47 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.46 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.45 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5311249 | 0.97 | MAPT (0.52) | SYKMAPTKLK7KLK5CTSK | |
| SCHEMBL1021938 | 0.83 | SYK (0.60) | SYKMAPTKLK7KLK5CTSK | |
| SCHEMBL4958981 | 0.83 | SYK (0.60) | SYKMAPTKLK7KLK5CTSK | |
| SCHEMBL918813 | 0.83 | SYK (0.60) | SYKMAPTKLK7KLK5CTSK | |
| SCHEMBL19345924 | 0.82 | JAK3 (0.63) | SYKMAPTKLK7KLK5SIRT2 | |
| SCHEMBL5332690 | 0.82 | SIRT2 (0.65) | SYKMAPTKLK7KLK5SIRT2 | |
| SCHEMBL5332693 | 0.82 | SIRT2 (0.65) | SYKMAPTKLK7KLK5SIRT2 | |
| SCHEMBL21900170 | 0.82 | SIRT2 (0.60) | SYKMAPTKLK7KLK5CTSK | |
| SCHEMBL21900169 | 0.82 | SIRT2 (0.60) | SYKMAPTKLK7KLK5CTSK | |
| SCHEMBL19295560 | 0.82 | SIRT2 (0.60) | SYKMAPTKLK7KLK5CTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007027742-A2 | SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-03-08 | — | — | WO | claimed |
| WO-2007027742-A2 | SMALL MOLECULE INTEGRIN α2βl/GPIa-IIa ANTAGONISTS | THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA (US) | 2007-03-08 | — | — | WO | disclosed |