Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.74 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.67 |
| ▸ | BBOX1 | O75936 | 1/20 | 0.66 |
| ▸ | ASPH | Q12797 | 1/20 | 0.66 |
| ▸ | KDM8 | Q8N371 | 1/20 | 0.66 |
| ▸ | MEN1 | O00255 | 8/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8237984 | 0.95 | HIF1A (0.68) | HIF1AEGLN1BBOX1ASPHKDM8 | |
| SCHEMBL8243641 | 0.85 | HIF1A (0.67) | HIF1AEGLN1BBOX1ASPHKDM8 | |
| SCHEMBL17578541 | 0.85 | HIF1A (1.00) | HIF1A | |
| SCHEMBL8244798 | 0.84 | HIF1A (0.67) | HIF1AEGLN1BBOX1ASPHKDM8 | |
| SCHEMBL2085626 | 0.83 | HIF1A (0.59) | HIF1AEGLN1BBOX1ASPHKDM8 | |
| SCHEMBL2382364 | 0.83 | EGLN1 (0.78) | EGLN1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8244110 | 0.82 | EGLN1 (0.70) | EGLN1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL8247183 | 0.82 | HIF1A (0.62) | HIF1AEGLN1BBOX1ASPHKDM8 | |
| SCHEMBL8244097 | 0.81 | EGLN1 (0.69) | EGLN1MEN1KMT2AKDM4EALDH1A1 | |
| SCHEMBL5310453 | 0.81 | EGLN1 (0.69) | EGLN1MEN1KMT2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | claimed |
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |