Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 13/20 | 0.68 |
| ▸ | PDE4B | Q07343 | 13/20 | 0.68 |
| ▸ | PDE4C | Q08493 | 13/20 | 0.68 |
| ▸ | PDE4D | Q08499 | 13/20 | 0.68 |
| ▸ | PDE3B | Q13370 | 13/20 | 0.55 |
| ▸ | PDE3A | Q14432 | 13/20 | 0.55 |
| ▸ | PDE5A | O76074 | 12/20 | 0.55 |
| ▸ | PDE1A | P54750 | 8/20 | 0.55 |
| ▸ | PDE1B | Q01064 | 8/20 | 0.55 |
| ▸ | PDE1C | Q14123 | 8/20 | 0.55 |
| ▸ | DPP4 | P27487 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5610553 | 0.87 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL27999650 | 0.85 | PDE4A (0.54) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL12507691 | 0.83 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL28263088 | 0.83 | PDE4A (0.51) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL27713096 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL16549378 | 0.81 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL12507244 | 0.80 | PDE4A (0.58) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL28668123 | 0.80 | PDE4A (0.47) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL7286620 | 0.79 | PDE4A (0.61) | PDE4APDE4BPDE4CPDE4DPDE3B | |
| SCHEMBL28010796 | 0.78 | PDE4A (0.44) | PDE4APDE4BPDE4CPDE4DPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104412985-B | Apply containing luxuriant and rich with fragrance heterocycle compound and preparation method thereof and Antiphytoviral | 南开大学 | 2016-12-28 | — | — | CN | disclosed |
| CN-104418765-B | Aromatic aminomethane compounds and preparation method thereof and Antiphytoviral are applied | 南开大学 | 2016-10-19 | — | — | CN | disclosed |
| CN-104412985-A | Phenanthrene-containing heterocycle compound and preparation method and application in resisting plant virus | UNIV NANKAI | 2015-03-18 | — | — | CN | disclosed |
| CN-104418765-A | Aryl methylamine compound and preparation method thereof and application in resisting plant virus | UNIV NANKAI | 2015-03-18 | — | — | CN | disclosed |
| WO-2015027772-A1 | PHENANTHRENE-CONTAINING HETEROCYCLIC COMPOUNDS, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF AS PLANT VIRUCIDES | 南开大学 (CN) | 2015-03-05 | — | — | WO | disclosed |
| CN-102150670-A | Application of phenanthroindolizidine and phenanthroquinolizidine derivatives and salts thereof in pesticides | UNIV NANKAI | 2011-08-17 | — | — | CN | disclosed |
| CN-101189968-B | Application of phenanthroindolizidine and phenanthroquinolizidine derivatives and salts thereof in pesticides | UNIV NANKAI | 2011-06-01 | — | — | CN | disclosed |
| CN-101189968-A | Application of phenanthroindolizidine and phenanthroquinolizidine derivatives and salts thereof in pesticides | UNIV NANKAI (CN) | 2008-06-04 | — | — | CN | disclosed |
| EP-1482937-A4 | NOVEL TYLOINDICINES AND RELATED PROCESSES, PHARMACEUTICAL COMPOSITIONS AND METHODS | UNIV YALE (US) | 2007-02-21 | — | — | EP | disclosed |
| US-20050222418-A1 | Novel tyloindicines and related processes, pharmaceutical compositions and methods | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2005-10-06 | — | — | US | disclosed |
| EP-1482937-A2 | NOVEL TYLOINDICINES AND RELATED PROCESSES, PHARMACEUTICAL COMPOSITIONS AND METHODS | YALE UNIVERSITY (US) | 2004-12-08 | — | — | EP | disclosed |
| WO-2003070166-A2 | NOVEL TYLOINDICINES AND RELATED PROCESSES, PHARMACEUTICAL COMPOSITIONS AND METHODS | YALE UNIVERSITY (US) | 2003-08-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050222418-A1 | Novel tyloindicines and related processes, pharmaceutical compositions and methods | IRF3, ILF3, ATL3 | PDE4A 2856/4885PDE4B 3778/4885PDE4C 2869/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.