Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 14/20 | 1.00 |
| ▸ | ESR2 | Q92731 | 13/20 | 1.00 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.69 |
| ▸ | AKR1B1 | P15121 | 3/20 | 0.69 |
| ▸ | AKR1B10 | O60218 | 2/20 | 0.69 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.69 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.69 |
| ▸ | MAOA | P21397 | 1/20 | 0.69 |
| ▸ | PDE5A | O76074 | 1/20 | 0.69 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.56 |
| ▸ | ACHE | P22303 | 1/20 | 0.56 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.56 |
| ▸ | PRKCA | P17252 | 1/20 | 0.56 |
| ▸ | BACE1 | P56817 | 1/20 | 0.56 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13893460 | 0.86 | ESR1 (0.82) | ESR1ESR2ABCG2AKR1B1AKR1B10 | |
| SCHEMBL17387053 | 0.84 | ESR1 (1.00) | ESR1ESR2ABCG2AKR1B1AKR1B10 | |
| SCHEMBL5310595 | 0.83 | ESR1 (1.00) | ESR1ESR2ABCG2AKR1B1AKR1B10 | |
| SCHEMBL17400391 | 0.82 | ESR1 (0.71) | ESR1ESR2ABCG2AKR1B1AKR1B10 | |
| SCHEMBL28931310 | 0.82 | ESR1 (0.71) | ESR1ESR2ABCG2AKR1B1AKR1B10 | |
| SCHEMBL15824268 | 0.82 | ESR1 (0.77) | ESR1ESR2ABCG2AKR1B1AKR1B10 | |
| Sophoraflavanone B SCHEMBL29396586 | 0.81 | ESR1 (1.00) | ESR1ESR2ABCG2AKR1B1AKR1B10 | |
| SCHEMBL1931876 | 0.81 | ESR1 (1.00) | ESR1ESR2ABCG2AKR1B1AKR1B10 | |
| Sophoraflavanone B SCHEMBL14304885 | 0.81 | ESR1 (1.00) | ESR1ESR2ABCG2AKR1B1AKR1B10 | |
| SCHEMBL28931296 | 0.81 | CYP19A1 (0.78) | ESR1ESR2ABCG2AKR1B1AKR1B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007053915-A2 | NARINGENIN DERIVATIVES WITH SELECTIVITY ON ERS | UNIVERSITEIT GENT (BE) | 2007-05-18 | — | — | WO | claimed |
| WO-2007053915-A2 | NARINGENIN DERIVATIVES WITH SELECTIVITY ON ERS | UNIVERSITEIT GENT (BE) | 2007-05-18 | — | — | WO | disclosed |