Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 15/20 | 0.65 |
| ▸ | PDGFRA | P16234 | 14/20 | 0.65 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.56 |
| ▸ | AXL | P30530 | 2/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895874 | 0.90 | PDGFRA (0.81) | KDRPDGFRARETAXLKIT | |
| SCHEMBL1892278 | 0.86 | AXL (0.71) | KDRPDGFRARETMETAXL | |
| SCHEMBL1889905 | 0.83 | KDR (0.81) | KDRPDGFRARETAURKAMET | |
| SCHEMBL31218163 | 0.82 | KDR (0.71) | KDRPDGFRARETAURKAMET | |
| SCHEMBL1892607 | 0.81 | AXL (0.70) | KDRPDGFRARETMETAXL | |
| SCHEMBL29258973 | 0.80 | AXL (0.81) | KDRPDGFRARETAURKAMET | |
| SCHEMBL1892648 | 0.79 | PDGFRA (0.81) | KDRPDGFRAMETAXL | |
| SCHEMBL29079734 | 0.79 | PDGFRA (0.63) | KDRPDGFRARETAURKAMET | |
| SCHEMBL7490931 | 0.79 | PDGFRA (1.00) | KDRPDGFRAKIT | |
| SCHEMBL12411986 | 0.78 | KDR (0.83) | KDRPDGFRAAXLKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1415987-B1 | NITROGENOUS AROMATIC RING COMPOUNDS AS ANTI CANCER AGENTS | EISAI R&D MAN CO LTD (JP) | 2007-02-28 | — | — | EP | claimed |