Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MELK | Q14680 | 19/20 | 0.53 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL529017 | 0.88 | MELK (0.66) | MELK | |
| SCHEMBL530939 | 0.88 | MELK (0.66) | MELK | |
| SCHEMBL12504873 | 0.84 | MELK (0.54) | MELK | |
| SCHEMBL15192193 | 0.83 | MELK (0.50) | MELK | |
| SCHEMBL529926 | 0.82 | MELK (0.56) | MELK | |
| SCHEMBL17435004 | 0.82 | MELK (0.69) | MELK | |
| SCHEMBL531044 | 0.80 | MELK (0.80) | MELK | |
| SCHEMBL531045 | 0.80 | MELK (0.80) | MELK | |
| SCHEMBL530561 | 0.78 | MELK (0.48) | MELK | |
| SCHEMBL17434885 | 0.78 | MELK (0.64) | MELK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2597955-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | OncoTherapy Science, Inc. (JP) | 2013-06-05 | — | — | EP | disclosed |
| WO-2012016082-A1 | QUINOLINE DERIVATIVES AND MELK INHIBITORS CONTAINING THE SAME | ONCOTHERAPY SCIENCE, INC. (JP) | 2012-02-02 | — | — | WO | disclosed |