Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 4/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.35 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2206836 | 0.88 | MAPK1 (0.50) | MAPK1CRBNDDB1USP2SMN1; SMN2 | |
| SCHEMBL327562 | 0.87 | MAPK1 (0.51) | MAPK1CRBNDDB1USP2SMN1; SMN2 | |
| SCHEMBL13665326 | 0.79 | HPGD (0.46) | MAPK1CRBNDDB1USP2SMN1; SMN2 | |
| SCHEMBL2206799 | 0.78 | NPSR1 (0.33) | — | |
| SCHEMBL21233487 | 0.77 | HPGD (0.50) | MAPK1CRBNDDB1USP2SMN1; SMN2 | |
| SCHEMBL1497667 | 0.77 | KMT2A (0.43) | CRBNKDM4E | |
| SCHEMBL3524396 | 0.76 | MAPK1 (0.58) | MAPK1USP2SMN1; SMN2KDM4EMAPT | |
| SCHEMBL20129368 | 0.74 | KDM4E (0.46) | MAPK1CRBNDDB1USP2SMN1; SMN2 | |
| SCHEMBL190307 | 0.74 | MAPK1 (0.59) | MAPK1CRBNDDB1USP2SMN1; SMN2 | |
| SCHEMBL31505455 | 0.74 | USP2 (0.51) | MAPK1USP2SMN1; SMN2KDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1866313-A1 | HIV INTEGRASE INHIBITORS | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-12-19 | — | — | EP | disclosed |
| WO-2006103399-A1 | HIV INTEGRASE INHIBITORS | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-10-05 | — | — | WO | disclosed |