Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.54 |
| ▸ | HTT | P42858 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.54 |
| ▸ | NR4A2 | P43354 | 4/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 3/20 | 0.54 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.54 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.54 |
| ▸ | APP | P05067 | 3/20 | 0.54 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.54 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.54 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.54 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | ACE2 | Q9BYF1 | 2/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5313535 | 0.90 | KDM4E (0.42) | KDM4EHSD17B10LMNAHTTKCNH2 | |
| SCHEMBL710488 | 0.86 | KDM4E (0.58) | KDM4EHSD17B10LMNAHTTKCNH2 | |
| SCHEMBL5305381 | 0.86 | CACNA2D1 (0.46) | KDM4EHSD17B10LMNAKCNH2CYP2D6 | |
| SCHEMBL29510895 | 0.86 | KDM4E (0.58) | KDM4EHSD17B10LMNAHTTKCNH2 | |
| SCHEMBL710054 | 0.81 | CDK1 (0.67) | KDM4EHSD17B10LMNAHTTKCNH2 | |
| SCHEMBL29510791 | 0.75 | KDM4E (0.44) | KDM4EHSD17B10LMNAHTTKCNH2 | |
| SCHEMBL708875 | 0.75 | KDM4E (0.44) | KDM4EHSD17B10LMNAHTTKCNH2 | |
| SCHEMBL707397 | 0.75 | KCNH2 (0.72) | KDM4EHSD17B10LMNAHTTKCNH2 | |
| SCHEMBL4745453 | 0.75 | KDM4E (0.43) | KDM4EHSD17B10LMNAHTTKCNH2 | |
| Chloroquine SCHEMBL28895653 | 0.75 | CHRM2 (0.90) | KDM4EHSD17B10LMNAHTTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007040469-A2 | CHLOROQUINE COUPLED COMPOSITIONS AND METHODS FOR THEIR SYNTHESIS | KOSAK KEN M (US) | 2007-04-12 | — | — | WO | disclosed |