Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 12/20 | 0.56 |
| ▸ | EGLN3 | Q9H6Z9 | 11/20 | 0.56 |
| ▸ | EGLN2 | Q96KS0 | 8/20 | 0.56 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8244823 | 0.90 | EGLN1 (0.66) | EGLN1EGLN3EGLN2MAPTKDM4E | |
| SCHEMBL8247337 | 0.83 | EGLN1 (0.75) | EGLN1EGLN3EGLN2 | |
| SCHEMBL8238770 | 0.83 | EGLN3 (0.62) | EGLN1EGLN3EGLN2KDM4EMEN1 | |
| SCHEMBL5309011 | 0.83 | EGLN1 (0.73) | EGLN1EGLN3EGLN2CYSLTR2KDM4E | |
| SCHEMBL8247330 | 0.83 | EGLN1 (0.65) | EGLN1EGLN3EGLN2CYSLTR2 | |
| SCHEMBL2382513 | 0.81 | HIF1A (0.59) | EGLN1 | |
| SCHEMBL5308391 | 0.81 | EGLN1 (0.82) | EGLN1EGLN3EGLN2KDM4EMEN1 | |
| SCHEMBL8244803 | 0.81 | EGLN1 (0.66) | EGLN1EGLN3EGLN2KDM4EMEN1 | |
| SCHEMBL8248302 | 0.81 | EGLN1 (0.61) | EGLN1EGLN3EGLN2CYSLTR2KDM4E | |
| SCHEMBL5311750 | 0.80 | EGLN1 (0.69) | EGLN1EGLN3EGLN2CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | claimed |
| WO-2007038571-A2 | PROLYL HYDROXYLASE ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 2007-04-05 | — | — | WO | disclosed |