Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | PLAU | P00749 | 2/20 | 0.46 |
| ▸ | SCN5A | Q14524 | 7/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.39 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.39 |
| ▸ | RET | P07949 | 2/20 | 0.38 |
| ▸ | KIF5B | P33176 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.38 |
| ▸ | CDK1 | P06493 | 1/20 | 0.38 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.38 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.37 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4470669 | 0.82 | MAPK8 (0.57) | SCN9APLAUSCN5AKCNH2MAPK8 | |
| SCHEMBL5308550 | 0.77 | ROCK1 (0.54) | SCN9ALMNAKCNH2MAPK8 | |
| SCHEMBL9647957 | 0.73 | MAPK8 (0.59) | MAPK8FLT3MKNK1MKNK2RET | |
| SCHEMBL4491188 | 0.72 | HTT (0.62) | SCN9ALMNAPLAUSCN5AKCNH2 | |
| SCHEMBL29430401 | 0.72 | HTT (0.62) | SCN9ALMNAPLAUSCN5AKCNH2 | |
| SCHEMBL3044816 | 0.71 | SCN9A (0.61) | SCN9ASCN5AKCNH2AURKADOT1L | |
| SCHEMBL5312139 | 0.71 | SCN9A (0.61) | SCN9ASCN5AKCNH2KDRDOT1L | |
| SCHEMBL4484400 | 0.70 | SYK (0.70) | SCN9ASCN5AMAPK8FLT3MKNK2 | |
| SCHEMBL14931251 | 0.70 | AURKA (0.51) | SCN9APLAUSCN5AKCNH2KDR | |
| SCHEMBL23704714 | 0.69 | AURKA (0.60) | SCN9APLAUSCN5AKCNH2KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007038387-A2 | COMPOUNDS AND METHODS FOR THE TREATMENT OF VIRUSES AND CANCER | YALE UNIVERSITY (US) | 2007-04-05 | — | — | WO | disclosed |