Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNK2 | Q07912 | 17/20 | 0.71 |
| ▸ | LCK | P06239 | 10/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | RAD52 | P43351 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | LYN | P07948 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 1/20 | 0.51 |
| ▸ | KDR | P35968 | 1/20 | 0.51 |
| ▸ | ZAP70 | P43403 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2965891 | 0.83 | TNK2 (1.00) | TNK2LCKABL1LYNBTK | |
| SCHEMBL2961061 | 0.83 | TNK2 (1.00) | TNK2LCKKMT2AMEN1RAD52 | |
| SCHEMBL2976792 | 0.82 | TNK2 (1.00) | TNK2LCKKMT2AMEN1RAD52 | |
| SCHEMBL2977182 | 0.80 | TNK2 (0.71) | TNK2LCKKMT2AMEN1RAD52 | |
| SCHEMBL2970697 | 0.80 | TNK2 (0.73) | TNK2LCKKMT2AMEN1RAD52 | |
| SCHEMBL2962544 | 0.78 | TNK2 (0.85) | TNK2LCKKMT2AMEN1RAD52 | |
| SCHEMBL2970642 | 0.78 | TNK2 (0.92) | TNK2LCKKMT2AMEN1RAD52 | |
| SCHEMBL2965913 | 0.76 | TNK2 (1.00) | TNK2LCKKMT2AMEN1EGFR | |
| SCHEMBL2973750 | 0.75 | TNK2 (0.65) | TNK2LCKKMT2AMEN1RAD52 | |
| SCHEMBL759082 | 0.74 | AURKA (0.77) | TNK2LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1768986-A2 | FURANOPYRIMIDINES | Amgen Inc. (US) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006004658-A2 | FURANOPYRIMIDINES | AMGEN INC. (US) | 2006-01-12 | — | — | WO | disclosed |