Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 18/20 | 0.80 |
| ▸ | MAPK13 | O15264 | 3/20 | 0.57 |
| ▸ | MAPK12 | P53778 | 3/20 | 0.57 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2847761 | 0.87 | MAPK14 (0.80) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL5313107 | 0.82 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL2842996 | 0.79 | MAPK14 (0.73) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL2851558 | 0.78 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL2847515 | 0.78 | MAPK14 (0.72) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL2851559 | 0.78 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL3226505 | 0.77 | MAPK14 (0.58) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL2845779 | 0.77 | MAPK14 (0.70) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL2842469 | 0.76 | MAPK14 (0.65) | MAPK14MAPK13MAPK12MAPK11KDM4E | |
| SCHEMBL7378916 | 0.74 | MAPK14 (1.00) | MAPK14MAPK13MAPK12MAPK11KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1853581-A1 | 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | MERCKLE GMBH (DE) | 2007-11-14 | — | — | EP | disclosed |
| WO-2006089798-A1 | 2-SULFINYL- AND 2-SULFONYL-SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR USE AS CYTOKINE INHIBITORS | MERCKLE GMBH (DE) | 2006-08-31 | — | — | WO | disclosed |