Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 20/20 | 0.70 |
| ▸ | FYN | P06241 | 2/20 | 0.57 |
| ▸ | EGFR | P00533 | 2/20 | 0.52 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.52 |
| ▸ | GAK | O14976 | 1/20 | 0.52 |
| ▸ | ABL1 | P00519 | 1/20 | 0.51 |
| ▸ | ABL2 | P42684 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3221052 | 0.94 | SRC (0.79) | SRCFYNABL1ABL2 | |
| SCHEMBL3224394 | 0.91 | SRC (0.68) | SRCFYNEGFRMAP2K1GAK | |
| SCHEMBL3219495 | 0.90 | SRC (0.67) | SRCFYNEGFRMAP2K1GAK | |
| SCHEMBL3220055 | 0.90 | SRC (0.75) | SRCFYNEGFRMAP2K1 | |
| SCHEMBL5311254 | 0.89 | SRC (0.88) | SRCFYNEGFRMAP2K1 | |
| SCHEMBL5257706 | 0.87 | SRC (0.62) | SRCFYNEGFRMAP2K1GAK | |
| SCHEMBL3213103 | 0.86 | SRC (0.85) | SRCFYNEGFRMAP2K1ABL1 | |
| SCHEMBL5311257 | 0.86 | SRC (0.63) | SRCFYNEGFRGAKABL1 | |
| SCHEMBL3225510 | 0.85 | SRC (0.75) | SRCFYNEGFRMAP2K1GAK | |
| SCHEMBL3228521 | 0.85 | SRC (0.67) | SRCFYNEGFRGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1268431-B1 | 3-CYANOQUINOLINES,3-CYANO-1,6-NAPHTHYRIDINES, AND 3-CYANO-1,7-NAPHTHYRIDINES AS PROTEIN KINASE INHIBITORS | WYETH CORP (US) | 2007-08-29 | — | — | EP | claimed |