Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of 1,4-Butanediol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | LMNA | P02545 | 5/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| 1,4-Butanediol SCHEMBL27302584 | 1.00 | TDP1 (0.71) | TDP1SMN1; SMN2TSHRALDH1A1LMNA | |
| 1,4-Butanediol SCHEMBL28655257 | 1.00 | TDP1 (0.71) | TDP1SMN1; SMN2TSHRALDH1A1LMNA | |
| 1,5-Pentanediol SCHEMBL9614570 | 0.97 | TDP1 (0.67) | TDP1SMN1; SMN2TSHRALDH1A1LMNA | |
| 1,6-Hexanediol SCHEMBL27408868 | 0.97 | TDP1 (0.67) | TDP1SMN1; SMN2TSHRALDH1A1LMNA | |
| 1,4-Butanediol SCHEMBL19856450 | 0.97 | TDP1 (0.67) | TDP1SMN1; SMN2TSHRALDH1A1LMNA | |
| 1,4-Butanediol SCHEMBL11103432 | 0.97 | TDP1 (0.67) | TDP1SMN1; SMN2TSHRALDH1A1LMNA | |
| 1,5-Pentanediol SCHEMBL9343564 | 0.97 | TDP1 (0.67) | TDP1SMN1; SMN2TSHRALDH1A1LMNA | |
| 1,6-Hexanediol SCHEMBL10442947 | 0.97 | TDP1 (0.67) | TDP1SMN1; SMN2TSHRALDH1A1LMNA | |
| 1,6-Hexanediol SCHEMBL3855738 | 0.97 | TDP1 (0.67) | TDP1SMN1; SMN2TSHRALDH1A1LMNA | |
| 1,4-Butanediol SCHEMBL4893040 | 0.94 | TDP1 (0.62) | TDP1SMN1; SMN2TSHRALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 271 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4329716-A1 | COMPOSITIONS AND METHODS FOR TREATING KERATIN FIBERS | L'OREAL (FR) | 2024-03-06 | — | — | EP | claimed |
| CN-113786513-A | Long-term stable recombinant collagen dressing and preparation method thereof | 西安德诺海思医疗科技有限公司 | 2021-12-14 | — | — | CN | claimed |
| CN-112662106-A | High-temperature-resistant oil-resistant thermoplastic vulcanized elastomer material and preparation method thereof | 安徽中翰高分子科技有限公司 | 2021-04-16 | — | — | CN | claimed |
| CN-106886127-B | Photoimprint resin composition, photoimprint resin film, and patterning process | 财团法人工业技术研究院 | 2020-09-01 | — | — | CN | claimed |
| EP-3135379-A1 | METHODS OF MAKING A FUEL | Xyleco, Inc. (US) | 2017-03-01 | — | — | EP | claimed |
| EP-3012025-A2 | METHOD OF DENSIFYING A FIBROUS COMPOSITION | Xyleco, Inc. (US) | 2016-04-27 | — | — | EP | claimed |
| CN-103820069-A | Double-component solvent-free polyurethane adhesive and preparation method thereof | NEWEAST PRINTING INK CO LTD | 2014-05-28 | — | — | CN | claimed |
| WO-2013095808-A1 | CHEMICAL GLASS TRANSITION TEMPERATURE REDUCER | BAKER HUGHES INCORPORATED (US) | 2013-06-27 | — | — | WO | claimed |
| US-20130161026-A1 | CHEMICAL GLASS TRANSITION TEMPERATURE REDUCER | BAKER HUGHES INCORPORATED (US) | 2013-06-27 | — | — | US | claimed |
| US-7989567-B2 | Method for production of water/oil repellent composition and article | ASAHI GLASS COMPANY, LIMITED (JP) | 2011-08-02 | — | — | US | claimed |
| EP-2032261-A2 | FIBROUS MATERIALS AND COMPOSITIONS | Xyleco, Inc. (US) | 2009-03-11 | — | — | EP | claimed |
| EP-1569977-B1 | CURABLE COMPOSITIONS | SHERWIN WILLIAMS CO (US) | 2008-06-11 | — | — | EP | claimed |
| WO-2007146922-A2 | FIBROUS MATERIALS AND COMPOSITIONS | XYLECO, INC. (US) | 2007-12-21 | — | — | WO | claimed |
| US-7279525-B2 | Curable compositions | THE SHERWIN-WILLIAMS COMPANY (US) | 2007-10-09 | — | — | US | claimed |
| US-20060073211-A1 | Cellulite formulation containing whole egg | MARENICK MICHAEL | 2006-04-06 | — | — | US | claimed |
| EP-1373452-B1 | LIQUID DETERGENT COMPOSITION EXHIBITING ENHANCED alpha-AMYLASE ENZYME STABILITY | PROCTER & GAMBLE (US) | 2006-01-18 | — | — | EP | claimed |
| EP-1167479-B1 | Underwater application of a paint | LESTIN & CO TAUCH BERGUNGS UND (AT) | 2004-09-22 | — | — | EP | claimed |
| US-6034203-A | USED FOR REACTION OF A POLYESTERS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2000-03-07 | — | — | US | claimed |
| US-5739230-A | CURABLE THROUGH A MICHAEL REACTION BETWEEN A COMPONENT HAVING A PLURALITY OF ALPHA,BETA-UNSATURATED CARBONYL GROUPS AND A COMPONENT HAVING A PLURALITY OF ACTIVATED METHYLENE GROUPS | NIPPON PAINT CO., LTD. (JP) | 1998-04-14 | — | — | US | claimed |
| US-4115169-A | Polyfunctional ester ketimines, adhesives derived therefrom and method for adhering materials | ROHM AND HAAS COMPANY (US) | 1978-09-19 | — | — | US | claimed |