Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 11/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 9/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | MEN1 | O00255 | 5/20 | 0.62 |
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | GAA | P10253 | 2/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | NPC1 | O15118 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | RECQL | P46063 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5314839 | 1.00 | MAPT (0.64) | MAPTKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5313730 | 0.83 | NPC1 (0.63) | MAPTKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5313736 | 0.83 | NPC1 (0.63) | MAPTKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL17673783 | 0.83 | NPC1 (0.63) | MAPTKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL16690183 | 0.82 | MAPT (0.46) | MAPTKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL16690172 | 0.82 | MAPK1 (0.47) | MAPTKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL16690249 | 0.80 | CES1 (0.47) | MAPTKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5308305 | 0.79 | KMT2A (0.70) | MAPTKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL5308301 | 0.79 | KMT2A (0.70) | MAPTKMT2AALDH1A1SMN1; SMN2MEN1 | |
| SCHEMBL27772048 | 0.78 | TDP1 (0.60) | MAPTKMT2AALDH1A1SMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070135442-A1 | Chroman compounds | ASTRAZENECA AB (SE) | 2007-06-14 | — | — | US | disclosed |
| WO-2007053094-A1 | CHROMAN COMPOUNDS AS 5 -HTlB ANTAGONISTS | ASTRAZENECA AB (SE) | 2007-05-10 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070135442-A1 | Chroman compounds | CYP3A43, CYP2C9, CYP2C8 | MAPT 3096/4885KMT2A 2880/4885ALDH1A1 1546/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.