Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 9/20 | 0.54 |
| ▸ | MAPK9 | P45984 | 9/20 | 0.54 |
| ▸ | MAPK10 | P53779 | 8/20 | 0.54 |
| ▸ | RET | P07949 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 8/20 | 0.49 |
| ▸ | CDK2 | P24941 | 2/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.49 |
| ▸ | MAP2K7 | O14733 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.49 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.49 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.49 |
| ▸ | MAP2K6 | P52564 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.49 |
| ▸ | CDK4 | P11802 | 7/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5315255 | 1.00 | MAPK8 (0.54) | MAPK8MAPK9MAPK10RETGSK3B | |
| SCHEMBL8233932 | 0.91 | CDK1 (0.56) | MAPK8MAPK9MAPK10RETGSK3B | |
| SCHEMBL5312695 | 0.82 | MAPK8 (0.56) | MAPK8MAPK9MAPK10RETGSK3B | |
| SCHEMBL5312697 | 0.82 | MAPK8 (0.56) | MAPK8MAPK9MAPK10RETGSK3B | |
| SCHEMBL8236162 | 0.81 | MAPK8 (0.51) | MAPK8MAPK9MAPK10RETGSK3B | |
| SCHEMBL8233938 | 0.80 | MAPK8 (0.54) | MAPK8MAPK9MAPK10RETGSK3B | |
| SCHEMBL8233906 | 0.79 | MAPK8 (0.51) | MAPK8MAPK9MAPK10RETGSK3B | |
| SCHEMBL5315799 | 0.78 | CDK4 (0.47) | MAPK8MAPK9MAPK10RETGSK3B | |
| SCHEMBL5315804 | 0.78 | CDK4 (0.47) | MAPK8MAPK9MAPK10RETGSK3B | |
| SCHEMBL5314789 | 0.78 | MAPK8 (0.50) | MAPK8MAPK9MAPK10RETGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129195-A2 | 4-PYRIMIDINE-5-AMINO-PYRAZOLE COMPOUNDS | PFIZER PRODUCTS INC. (US) | 2007-11-15 | — | — | WO | disclosed |