Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX7 | Q99572 | 10/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22314647 | 0.89 | NPC1 (0.59) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL13495145 | 0.82 | NPC1 (0.67) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23402488 | 0.79 | NPC1 (0.54) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23399584 | 0.76 | NPC1 (0.52) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23401505 | 0.75 | NPC1 (0.51) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL23401146 | 0.75 | NPC1 (0.50) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL18770513 | 0.75 | NPC1 (0.58) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL10630429 | 0.74 | NPC1 (0.50) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL28786731 | 0.74 | POLB (0.59) | P2RX7NPC1RAB9AMEN1KMT2A | |
| SCHEMBL14495713 | 0.73 | NPC1 (0.47) | P2RX7NPC1RAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070148185-A1 | Novel therapeutic target for protozoal diseases | VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY | 2007-06-28 | — | — | US | claimed |
| WO-2007047579-A2 | A NOVEL THERAPEUTIC TARGET FOR PROTOZOAL DISEASES | VIRGINIA TECH INTELLECTUAL PROPERTIES, INC. (US) | 2007-04-26 | — | — | WO | claimed |