Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 19/20 | 0.71 |
| ▸ | HDAC4 | P56524 | 19/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 19/20 | 0.71 |
| ▸ | HDAC7 | Q8WUI4 | 19/20 | 0.71 |
| ▸ | HDAC2 | Q92769 | 19/20 | 0.71 |
| ▸ | HDAC10 | Q969S8 | 19/20 | 0.71 |
| ▸ | HDAC11 | Q96DB2 | 19/20 | 0.71 |
| ▸ | HDAC8 | Q9BY41 | 19/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.71 |
| ▸ | HDAC9 | Q9UKV0 | 19/20 | 0.71 |
| ▸ | HDAC5 | Q9UQL6 | 19/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317655 | 0.87 | KMT2A (0.61) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL8239739 | 0.87 | HDAC3 (0.68) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5315936 | 0.87 | KMT2A (0.58) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5318602 | 0.86 | HDAC3 (0.76) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14500112 | 0.79 | HDAC3 (0.60) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5317714 | 0.79 | HDAC3 (0.91) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14500111 | 0.78 | HDAC3 (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5318034 | 0.78 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14500110 | 0.77 | HDAC3 (0.79) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5341620 | 0.77 | HDAC3 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007067993-A1 | INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |
| WO-2007067993-A1 | INHIBITORS OF HISTONE DEACETYLASE FOR THE TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2007-06-14 | — | — | WO | disclosed |