Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.59 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.59 |
| ▸ | MAPK11 | Q15759 | 3/20 | 0.59 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.59 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.59 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.59 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.59 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.59 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.49 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5316364 | 1.00 | MAPK14 (0.59) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2943315 | 0.95 | MAPK14 (0.64) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2943312 | 0.95 | MAPK14 (0.64) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2944573 | 0.88 | MAPK14 (0.77) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2944570 | 0.88 | MAPK14 (0.77) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2948180 | 0.86 | MAPK14 (0.60) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2944578 | 0.86 | MAPK14 (0.71) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2945163 | 0.86 | MAPK14 (0.71) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL2946998 | 0.86 | MAPK14 (0.71) | MAPK14MAPK8MAPK11MAPK9MAPK10 | |
| SCHEMBL14266277 | 0.86 | MAPK14 (0.71) | MAPK14MAPK8MAPK11MAPK9MAPK10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1685131-B1 | HYDROXYALKYL SUBSTITUTED PYRIDO-7-PYRIMIDIN-7-ONES | HOFFMANN LA ROCHE (CH) | 2007-03-07 | — | — | EP | disclosed |