Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 11/20 | 0.50 |
| ▸ | SRC | P12931 | 10/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 10/20 | 0.50 |
| ▸ | EGFR | P00533 | 10/20 | 0.50 |
| ▸ | PIK3CA | P42336 | 9/20 | 0.50 |
| ▸ | PIK3CB | P42338 | 9/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.50 |
| ▸ | PRKDC | P78527 | 9/20 | 0.50 |
| ▸ | ABL1 | P00519 | 8/20 | 0.50 |
| ▸ | HCK | P08631 | 8/20 | 0.50 |
| ▸ | MTOR | P42345 | 8/20 | 0.50 |
| ▸ | EPHB4 | P54760 | 8/20 | 0.50 |
| ▸ | BTK | Q06187 | 3/20 | 0.50 |
| ▸ | LCK | P06239 | 2/20 | 0.49 |
| ▸ | TEK | Q02763 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 3/20 | 0.47 |
| ▸ | IGF1R | P08069 | 2/20 | 0.46 |
| ▸ | PI4KB | Q9UBF8 | 3/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL400100 | 0.94 | KDR (0.50) | KDRSRCPIK3CDEGFRPIK3CA | |
| SCHEMBL401554 | 0.92 | KDR (0.51) | KDRSRCPIK3CDEGFRPIK3CA | |
| Carbamic Acid SCHEMBL19244770 | 0.91 | PIK3CD (0.58) | KDRSRCPIK3CDEGFRPIK3CA | |
| SCHEMBL402040 | 0.91 | PIK3CD (0.61) | KDRSRCPIK3CDEGFRPIK3CA | |
| SCHEMBL19244961 | 0.90 | KDR (0.55) | KDRSRCPIK3CDEGFRPIK3CA | |
| SCHEMBL399768 | 0.88 | PIK3CD (0.51) | KDRSRCPIK3CDEGFRPIK3CA | |
| SCHEMBL398133 | 0.87 | PIK3CD (0.51) | KDRSRCPIK3CDEGFRPIK3CA | |
| SCHEMBL402191 | 0.87 | PIK3CD (0.51) | KDRSRCPIK3CDEGFRPIK3CA | |
| SCHEMBL398302 | 0.85 | KDR (0.53) | KDRSRCPIK3CDEGFRPIK3CA | |
| SCHEMBL27961651 | 0.85 | EGFR (0.51) | KDRSRCPIK3CDEGFRPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1740591-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI Pharmaceuticals, Inc. (US) | 2007-01-10 | — | — | EP | disclosed |
| WO-2005097800-A1 | 6,6-BICYCLIC RING SUBSTITUTED HETEROBICYCLIC PROTEIN KINASE INHIBITORS | OSI PHARMACEUTICALS, INC. (US) | 2005-10-20 | — | — | WO | disclosed |