Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 9/20 | 0.78 |
| ▸ | HTR1B | P28222 | 7/20 | 0.78 |
| ▸ | HTR2A | P28223 | 7/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.78 |
| ▸ | MEN1 | O00255 | 3/20 | 0.78 |
| ▸ | MAPT | P10636 | 3/20 | 0.78 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.78 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.78 |
| ▸ | TP53 | P04637 | 2/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.78 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.78 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.78 |
| ▸ | HPGD | P15428 | 2/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.78 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.78 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.78 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.77 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.77 |
| ▸ | HTR2C | P28335 | 2/20 | 0.77 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2360553 | 0.88 | HTR1D (1.00) | HTR1DHTR1BHTR2AMAPK1MEN1 | |
| SCHEMBL29390887 | 0.88 | HTR1D (1.00) | HTR1DHTR1BHTR2AMAPK1MEN1 | |
| Hydrochloric Acid SCHEMBL25382964 | 0.87 | HTR1D (1.00) | HTR1DHTR1BHTR2AMAPK1MEN1 | |
| SCHEMBL6925617 | 0.86 | HTR1D (0.85) | HTR1DHTR1BHTR2AMAPK1MEN1 | |
| SCHEMBL5316782 | 0.86 | HTR1D (0.74) | HTR1DHTR1BHTR2AMAPK1MEN1 | |
| SCHEMBL6923904 | 0.86 | HTR1D (0.84) | HTR1DHTR1BHTR2AMAPK1MEN1 | |
| SCHEMBL5318126 | 0.85 | HTR1D (0.71) | HTR1DHTR1BHTR2AMAPK1MEN1 | |
| SCHEMBL8744156 | 0.85 | HTR1D (0.72) | HTR1DHTR1BHTR2AMAPK1MEN1 | |
| SCHEMBL7450572 | 0.85 | HTR1D (0.91) | HTR1DHTR1BHTR2AMAPK1MEN1 | |
| SCHEMBL8654316 | 0.84 | HTR1D (0.74) | HTR1DHTR1BHTR2AMAPK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733048-A1 | HETEROCYCLIC BIPHENYLYLAMIDES USEFUL AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-09-25 | — | — | EP | claimed |
| WO-1995015954-A1 | HETEROCYCLIC BIPHENYLYLAMIDES USEFUL AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-15 | — | — | WO | claimed |
| WO-2007077457-A9 | TREATMENT OF EQUINE LAMINITIS WITH 5-HT1B/ 1D ANTAGONISTS | ROYAL VETERINARY COLLEGE (GB) | 2007-10-18 | — | — | WO | disclosed |
| US-5801170-A | Heterocyclic biphenylylamides useful as 5HT1D antagonists | SMITHKLINE BEECHAM PLC (GB) | 1998-09-01 | — | — | US | disclosed |
| EP-0733048-A1 | HETEROCYCLIC BIPHENYLYLAMIDES USEFUL AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-09-25 | — | — | EP | disclosed |
| WO-1995015954-A1 | HETEROCYCLIC BIPHENYLYLAMIDES USEFUL AS 5HT1D ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-06-15 | — | — | WO | disclosed |