Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | TOP2A | P11388 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 5/20 | 0.36 |
| ▸ | FEN1 | P39748 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4057540 | 0.86 | ADORA1 (0.45) | HSD17B10ALDH1A1MAPTLMNAFEN1 | |
| SCHEMBL4052552 | 0.85 | ADORA1 (0.37) | HSD17B10TNFALDH1A1MAPTTOP2A | |
| SCHEMBL4048802 | 0.85 | ADORA1 (0.37) | HSD17B10TNFALDH1A1MAPTTOP2A | |
| SCHEMBL4053146 | 0.84 | ADORA1 (0.43) | HSD17B10ALDH1A1MAPTLMNAGAA | |
| SCHEMBL4051228 | 0.83 | ADORA1 (0.40) | HSD17B10ALDH1A1MAPTLMNAGAA | |
| SCHEMBL4052382 | 0.79 | ADORA1 (0.40) | HSD17B10ALDH1A1MAPTGAAMEN1 | |
| SCHEMBL4370564 | 0.79 | ADORA1 (0.36) | HSD17B10ALDH1A1MAPTLMNAGAA | |
| SCHEMBL4059427 | 0.79 | ADORA1 (0.41) | HSD17B10ALDH1A1MAPTLMNAMEN1 | |
| SCHEMBL4051184 | 0.78 | HTT (0.39) | HSD17B10ALDH1A1MAPTLMNAGAA | |
| SCHEMBL4057121 | 0.78 | ADORA1 (0.40) | HSD17B10ALDH1A1MAPTLMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1781621-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | Laboratorios Almirall, S.A. (ES) | 2007-05-09 | — | — | EP | disclosed |
| WO-2005123693-A1 | PYRIDAZIN-3(2H)-ONE DERIVATIVES AND THEIR USE AS PDE4 INHIBITORS | LABORATORIOS ALMIRALL, S.A. (ES) | 2005-12-29 | — | — | WO | disclosed |