Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | PI4KA | P42356 | 1/20 | 0.56 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.56 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.56 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.56 |
| ▸ | P2RX3 | P56373 | 4/20 | 0.54 |
| ▸ | P2RX1 | P51575 | 3/20 | 0.54 |
| ▸ | P2RX4 | Q99571 | 3/20 | 0.54 |
| ▸ | AMD1 | P17707 | 2/20 | 0.46 |
| ▸ | PRKAB2 | O43741 | 1/20 | 0.44 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.44 |
| ▸ | PRKAA2 | P54646 | 1/20 | 0.44 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.44 |
| ▸ | PRKAG3 | Q9UGI9 | 1/20 | 0.44 |
| ▸ | PRKAG2 | Q9UGJ0 | 1/20 | 0.44 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1796855 | 1.00 | RXFP1 (0.57) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL16579246 | 0.89 | RXFP1 (0.58) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1798271 | 0.89 | PI4KA (0.73) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL3407241 | 0.89 | PI4KA (0.73) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1798145 | 0.89 | RXFP1 (0.57) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL30544933 | 0.89 | PI4KA (0.73) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1795772 | 0.86 | RXFP1 (0.54) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL5672710 | 0.85 | PI4KA (0.63) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL1799672 | 0.85 | RXFP1 (0.54) | RXFP1PI4KAPI4K2BPI4K2API4KB | |
| SCHEMBL11889816 | 0.85 | PI4KA (0.80) | RXFP1PI4KAPI4K2BPI4K2API4KB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848718-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006084281-A1 | INHIBITORS OF E1 ACTIVATING ENZYMES | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2006-08-10 | — | — | WO | disclosed |