Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 20/20 | 0.60 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.55 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.46 |
| ▸ | STRADA | Q7RTN6 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317994 | 1.00 | MAPK14 (0.60) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL5322684 | 0.85 | MAPK14 (0.81) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL5322678 | 0.85 | MAPK14 (0.81) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL5322727 | 0.84 | MAPK14 (0.55) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL14465350 | 0.83 | MAPK14 (0.57) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3527202 | 0.83 | MAPK14 (0.59) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3521990 | 0.82 | MAPK14 (0.67) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3522198 | 0.82 | MAPK14 (0.67) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3524570 | 0.78 | MAPK14 (0.77) | MAPK14MAPK11ROCK2MAPK12STRADA | |
| SCHEMBL3524504 | 0.77 | MAPK14 (0.64) | MAPK14MAPK11ROCK2MAPK12STRADA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007081901-A2 | PYRIMIDINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2007-07-19 | — | — | WO | disclosed |