Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lorcaserin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C known ✓ | P28335 | 20/20 | 0.94 |
| ▸ | HTR2A | P28223 | 20/20 | 0.94 |
| ▸ | HTR2B | P41595 | 18/20 | 0.94 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.94 |
| ▸ | HTR1A | P08908 | 1/20 | 0.94 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.94 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.94 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.94 |
| ▸ | CNR1 | P21554 | 1/20 | 0.94 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.94 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.94 |
| ▸ | HRH1 | P35367 | 1/20 | 0.94 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.94 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Lorcaserin SCHEMBL30418169 | 1.00 | HTR2A (0.94) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL173222 | 1.00 | HTR2A (0.94) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL19179796 | 1.00 | HTR2A (0.94) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL173223 | 1.00 | HTR2A (0.94) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL3757691 | 1.00 | HTR2A (0.94) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL5318606 | 1.00 | HTR2A (0.94) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL174044 | 0.98 | HTR2A (0.97) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL174046 | 0.98 | HTR2A (0.97) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL1954700 | 0.98 | HTR2A (0.97) | HTR2AHTR2CHTR2BADRB1HTR1A | |
| Lorcaserin SCHEMBL173899 | 0.98 | HTR2A (0.97) | HTR2AHTR2CHTR2BADRB1HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115784911-A | Synthetic method of 1- [2- (4-chlorophenyl) -ethylamino ] -2-propanol | 山东省药学科学院 | 2023-03-14 | — | — | CN | disclosed |
| CN-112358406-A | Preparation method of lorcaserin intermediate | 山东省药学科学院 | 2021-02-12 | — | — | CN | disclosed |
| CN-106478506-B | The preparation method of half light green Ka Selin hydrochloride | 山东科兴生物制品有限公司 | 2019-03-15 | — | — | CN | disclosed |
| CN-106478506-A | The preparation method of half light green Ka Selin hydrochlorate | 山东科兴生物制品有限公司 | 2017-03-08 | — | — | CN | disclosed |
| EP-1838677-A2 | CRYSTALLINE FORMS OF (R)-8-CHLORO-1-METHYL- 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE | Arena Pharmaceuticals, Inc. (US) | 2007-10-03 | — | — | EP | disclosed |
| WO-2006069363-A2 | CRYSTALLINE FORMS OF (R)-8-CHLORO-1-METHYL- 2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE | ARENA PHARMACEUTICALS, INC. (US) | 2006-06-29 | — | — | WO | disclosed |