Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 13/20 | 0.79 |
| ▸ | HDAC4 | P56524 | 13/20 | 0.79 |
| ▸ | HDAC1 | Q13547 | 13/20 | 0.79 |
| ▸ | HDAC7 | Q8WUI4 | 13/20 | 0.79 |
| ▸ | HDAC2 | Q92769 | 13/20 | 0.79 |
| ▸ | HDAC10 | Q969S8 | 13/20 | 0.79 |
| ▸ | HDAC11 | Q96DB2 | 13/20 | 0.79 |
| ▸ | HDAC8 | Q9BY41 | 13/20 | 0.79 |
| ▸ | HDAC6 | Q9UBN7 | 13/20 | 0.79 |
| ▸ | HDAC9 | Q9UKV0 | 13/20 | 0.79 |
| ▸ | HDAC5 | Q9UQL6 | 13/20 | 0.79 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4804228 | 0.90 | HDAC3 (0.78) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5319421 | 0.89 | HDAC3 (0.80) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL14164268 | 0.88 | HDAC1 (1.00) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5335863 | 0.87 | HDAC3 (0.62) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4180681 | 0.84 | HDAC3 (0.60) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| Hydroxyamine SCHEMBL6418576 | 0.82 | HDAC3 (0.57) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5337583 | 0.81 | HDAC3 (0.63) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL4910382 | 0.80 | HDAC2 (0.77) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5336978 | 0.80 | HDAC3 (0.53) | HDAC3HDAC4HDAC1HDAC7HDAC2 | |
| SCHEMBL5319525 | 0.80 | HDAC2 (0.67) | HDAC3HDAC4HDAC1HDAC7HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1755601-A2 | INHIBITORS OF HISTONE DEACETYLASE | Miikana Therapeutics, Inc. (US) | 2007-02-28 | — | — | EP | claimed |
| WO-2005086898-A2 | INHIBITORS OF HISTONE DEACETYLASE | MIIKANA THERAPEUTICS, INC. (US) | 2005-09-22 | — | — | WO | claimed |