Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 4/20 | 0.44 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.44 |
| ▸ | IKBKB | O14920 | 7/20 | 0.43 |
| ▸ | KDR | P35968 | 4/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4717449 | 0.77 | KMT2A (0.53) | PDGFRB | |
| SCHEMBL4718840 | 0.76 | MAPK14 (0.54) | ERBB2 | |
| SCHEMBL4897449 | 0.76 | EGFR (0.41) | EGFRERBB2KDRPDGFRB | |
| SCHEMBL3251978 | 0.73 | GRM5 (0.55) | EGFRERBB2GRM4 | |
| SCHEMBL5373728 | 0.72 | MAPK14 (0.49) | ERBB2 | |
| SCHEMBL4716464 | 0.70 | PTPN11 (0.52) | KDRPDGFRBPTPN11LCKTEK | |
| SCHEMBL20530116 | 0.70 | EGFR (0.61) | EGFRIKBKBPTPN11 | |
| SCHEMBL4714699 | 0.68 | MEN1 (0.57) | KDRLCKTEK | |
| SCHEMBL7133734 | 0.68 | MAPT (0.50) | EGFRIKBKBPTPN11 | |
| SCHEMBL3580009 | 0.68 | LCK (0.59) | EGFRKDRPDGFRBPTPN11LCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1848715-A1 | COMPOUNDS HAVING TIE2 (TEK) INHIBITORY ACTIVITY | AstraZeneca AB (SE) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006082404-A1 | COMPOUNDS HAVING TIE2 (TEK) INHIBITORY ACTIVITY | ASTRAZENECA AB (SE) | 2006-08-10 | — | — | WO | disclosed |