SCHEMBL5319675

SCHEMBL5319675

Brc1ncccc1-c1ncc[nH]1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CSNK1A1 P48729 1/20 0.47
TYRO3 Q06418 1/20 0.47
DYRK1B Q9Y463 1/20 0.47
NISCH Q9Y2I1 2/20 0.47
MTOR P42345 1/20 0.47
ADK P55263 1/20 0.47
ALDH1A1 P00352 2/20 0.42
MEN1 O00255 1/20 0.42
KMT2A Q03164 1/20 0.42
CASP6 P55212 1/20 0.41
IDO1 P14902 1/20 0.40
ADRA1A P35348 2/20 0.39
ADRA2A P08913 4/20 0.37
ADRA2C P18825 3/20 0.37
ADRA2B P18089 2/20 0.37
TRIM24 O15164 1/20 0.37
TRIM33 Q9UPN9 1/20 0.37
MC4R P32245 2/20 0.37
TRPV1 Q8NER1 1/20 0.37
ADRA1D P25100 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31627268 1.00 CSNK1A1 (0.47) CSNK1A1TYRO3DYRK1BNISCHMTOR
SCHEMBL9287236 0.79 NISCH (0.64) CSNK1A1TYRO3DYRK1BNISCHMTOR
SCHEMBL30222222 0.78 NISCH (0.53) CSNK1A1TYRO3DYRK1BNISCHMTOR
SCHEMBL7537761 0.78 CSNK1A1 (0.49) CSNK1A1TYRO3DYRK1BNISCHMTOR
SCHEMBL1369295 0.78 NISCH (0.53) CSNK1A1TYRO3DYRK1BNISCHMTOR
SCHEMBL14886257 0.77 NISCH (0.61) CSNK1A1TYRO3DYRK1BNISCHMTOR
SCHEMBL3600525 0.77 NISCH (0.48) CSNK1A1TYRO3DYRK1BNISCHMTOR
SCHEMBL31627252 0.77 CSNK1A1 (0.51) CSNK1A1TYRO3DYRK1BNISCHMTOR
SCHEMBL22408613 0.77 CSNK1A1 (0.47) CSNK1A1TYRO3DYRK1BNISCHMTOR
Ammonia Solution, Strong SCHEMBL28778713 0.77 NISCH (0.52) CSNK1A1TYRO3DYRK1BNISCHMTOR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2025128834-A1 AKT1 MODULATORS ALTEROME THERAPEUTICS, INC. (US) 2025-06-19 WO disclosed
EP-2868660-B1 ANTITUMOR EFFECT POTENTIATOR COMPRISING AN IMIDAZOOXAZINE COMPOUND TAIHO PHARMACEUTICAL CO LTD (JP) 2017-12-27 EP disclosed
US-9375434-B2 Antitumor effect potentiator composed of imidazooxazine compound TAIHO PHARMACEUTICAL CO., LTD. (JP) 2016-06-28 US disclosed
US-9289431-B2 2016-03-22 US disclosed
EP-2698372-B1 NOVEL IMIDAZO-OXAZINE COMPOUND OR SALT THEREOF TAIHO PHARMACEUTICAL CO LTD (JP) 2016-02-03 EP disclosed
US-20150164909-A1 ANTITUMOR EFFECT POTENTIATOR COMPOSED OF IMIDAZOOXAZINE COMPOUND TAIHO PHARMACEUTICAL CO., LTD. (JP) 2015-06-18 US disclosed
EP-2868660-A1 ANTITUMOR EFFECT POTENTIATOR COMPOSED OF IMIDAZOOXAZINE COMPOUND Taiho Pharmaceutical Co., Ltd. (JP) 2015-05-06 EP disclosed
US-8772283-B2 Imidazo-oxazine compound or salt thereof TAIHO PHARMACEUTICAL CO., LTD. (JP) 2014-07-08 US disclosed
EP-2698372-A1 NOVEL IMIDAZO-OXAZINE COMPOUND OR SALT THEREOF Taiho Pharmaceutical Co., Ltd. (JP) 2014-02-19 EP disclosed
US-20140005185-A1 NOVEL IMIDAZO-OXAZINE COMPOUND OR SALT THEREOF TAIHO PHARMACEUTICAL CO., LTD. (JP) 2014-01-02 US disclosed
EP-1861079-A1 ARYLSULFONYL BENZYL ETHERS AS 5-HT2A ANTAGONISTS MERCK SHARP & DOHME LTD. (GB) 2007-12-05 EP disclosed
WO-2006097766-A1 ARYLSULFONYL BENZYL ETHERS AS 5-HT2A ANTAGONISTS MERCK SHARP & DOHME LIMITED (GB) 2006-09-21 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150164909-A1 ANTITUMOR EFFECT POTENTIATOR COMPOSED OF IMIDAZOOXAZINE COMPOUND H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, HCCS, TPD52L2 CSNK1A1 997/4885TYRO3 2085/4885DYRK1B 2330/4885
US-20140005185-A1 NOVEL IMIDAZO-OXAZINE COMPOUND OR SALT THEREOF IKZF3, IKZF2, IKZF1 CSNK1A1 180/4885TYRO3 2211/4885DYRK1B 1763/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.