Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 18/20 | 0.69 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
| ▸ | TNK1 | Q13470 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532272 | 0.86 | PARP1 (0.75) | PARP1TNK2TNK1DRD2 | |
| SCHEMBL531932 | 0.82 | PARP1 (1.00) | PARP1 | |
| SCHEMBL532169 | 0.78 | PARP1 (0.64) | PARP1TNK1 | |
| SCHEMBL532488 | 0.78 | PARP1 (0.75) | PARP1DRD2DRD3 | |
| SCHEMBL532132 | 0.76 | PARP1 (0.77) | PARP1TNK2TNK1 | |
| SCHEMBL532023 | 0.75 | PARP1 (1.00) | PARP1 | |
| SCHEMBL532342 | 0.74 | PARP1 (0.86) | PARP1 | |
| SCHEMBL531939 | 0.74 | PARP1 (1.00) | PARP1 | |
| SCHEMBL532968 | 0.74 | PARP1 (1.00) | PARP1 | |
| SCHEMBL532080 | 0.73 | PARP1 (0.84) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2415767-A1 | Poly (ADP-ribose) Polymerase (PARP) Inhibitors | Takeda Pharmaceutical Company Limited (JP) | 2012-02-08 | — | — | EP | disclosed |