Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | PPARD | Q03181 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5323847 | 0.87 | GRM2 (0.43) | GRM2 | |
| SCHEMBL5317513 | 0.85 | GRM2 (0.39) | GRM2 | |
| SCHEMBL5325266 | 0.85 | GRM2 (0.42) | GRM2 | |
| SCHEMBL5319428 | 0.85 | PPARG (0.43) | GRM2PPARGPPARD | |
| SCHEMBL5320733 | 0.83 | GRM2 (0.47) | GRM2NPC1RAB9AHDAC1PPARG | |
| SCHEMBL5321101 | 0.83 | GRM2 (0.42) | GRM2 | |
| SCHEMBL5317788 | 0.82 | GRM2 (0.56) | GRM2 | |
| SCHEMBL5321246 | 0.82 | GRM2 (0.56) | GRM2 | |
| SCHEMBL5320848 | 0.81 | GRM2 (0.43) | GRM2 | |
| SCHEMBL5320246 | 0.81 | GRM2 (0.59) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773774-A2 | HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006014918-A2 | HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |