Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 15/20 | 0.56 |
| ▸ | SYK | P43405 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4055658 | 0.83 | AURKA (0.50) | AURKAAURKBSYK | |
| SCHEMBL4057397 | 0.79 | AURKA (0.51) | AURKAAURKBSYK | |
| SCHEMBL4056859 | 0.79 | AURKA (0.72) | AURKAAURKBSYK | |
| SCHEMBL4061496 | 0.77 | AURKA (0.53) | AURKAAURKBSYK | |
| SCHEMBL4059106 | 0.76 | AURKA (0.75) | AURKAAURKBSYK | |
| SCHEMBL4057365 | 0.76 | AURKA (0.72) | AURKAAURKBSYK | |
| SCHEMBL4065204 | 0.74 | AURKA (0.67) | AURKAAURKBSYK | |
| SCHEMBL4055807 | 0.74 | AURKA (0.59) | AURKAAURKBSYK | |
| SCHEMBL4057001 | 0.73 | AURKA (0.53) | AURKAAURKBSYK | |
| SCHEMBL4057927 | 0.72 | AURKA (1.00) | AURKAAURKBSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1794148-A1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-13 | — | — | EP | claimed |
| WO-2006032518-A1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-30 | — | — | WO | claimed |
| EP-1794148-A1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006032518-A1 | NOVEL PHTHALAZINONE DERIVATIVES, AS AURORA-A KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-03-30 | — | — | WO | disclosed |