SCHEMBL5320258

SCHEMBL5320258

CCc1c(-c2nnc(C(=O)O)o2)nn(-c2ccc(Cl)cc2Cl)c1-c1ccc(Br)cc1

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
CNR2 P34972 15/20 0.63
CNR1 P21554 2/20 0.58
KCNH2 Q12809 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4461639 0.90 CNR2 (0.59) CNR2CNR1
SCHEMBL4479354 0.90 CNR2 (0.59) CNR2CNR1
SCHEMBL4462655 0.86 CNR2 (0.68) CNR2CNR1
SCHEMBL4464818 0.85 CNR2 (0.67) CNR2CNR1
SCHEMBL923025 0.84 CNR2 (0.66) CNR2CNR1
SCHEMBL922623 0.84 CNR2 (0.89) CNR2
SCHEMBL4464717 0.84 CNR2 (0.65) CNR2CNR1
SCHEMBL4468784 0.83 CNR2 (0.62) CNR2CNR1
SCHEMBL923396 0.83 CNR2 (0.64) CNR2CNR1
SCHEMBL923697 0.82 CNR2 (0.77) CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1853595-A1 (1,5-DIPHENYL-1H-PYRAZOL-3-YL)OXADIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS Sanofi-Aventis (FR) 2007-11-14 EP disclosed
WO-2006087480-A1 (1,5-DIPHENYL-1H-PYRAZOL-3-YL)OXADIAZOLE DERIVATIVES, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS SANOFI-AVENTIS (FR) 2006-08-24 WO disclosed