Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 9/20 | 0.56 |
| ▸ | KDR | P35968 | 2/20 | 0.48 |
| ▸ | TP53 | P04637 | 2/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4734114 | 0.89 | EGFR (0.64) | EGFRERBB2KDRTP53LMNA | |
| SCHEMBL4733365 | 0.87 | AURKA (0.52) | TP53AURKARPS6KB1MAPTLMNA | |
| SCHEMBL1095766 | 0.80 | EGFR (0.65) | EGFRERBB2KDRRET | |
| SCHEMBL1105358 | 0.80 | EGFR (0.65) | EGFRERBB2KDRRET | |
| SCHEMBL4734445 | 0.79 | EGFR (0.64) | EGFRERBB2KDRRET | |
| SCHEMBL1105380 | 0.79 | EGFR (0.64) | EGFRERBB2KDRRET | |
| SCHEMBL1095542 | 0.78 | EGFR (0.62) | EGFRERBB2KDRAURKARPS6KB1 | |
| SCHEMBL1105347 | 0.78 | EGFR (0.62) | EGFRERBB2KDRAURKARPS6KB1 | |
| SCHEMBL4735963 | 0.76 | EGFR (0.69) | EGFRERBB2KDRLMNAHTT | |
| SCHEMBL1105321 | 0.76 | EGFR (0.69) | EGFRERBB2KDRLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007081630-A2 | SUBSTITUTED PYRIMIDINYL KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-07-19 | — | — | WO | disclosed |