Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 7/20 | 0.40 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | EDNRB | P24530 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5789923 | 0.93 | EDNRA (0.42) | EDNRAAGTR1EDNRB | |
| SCHEMBL5530779 | 0.85 | EDNRA (0.58) | EDNRAAGTR1EDNRB | |
| SCHEMBL4774360 | 0.83 | EDNRA (0.42) | EDNRAAGTR1EDNRB | |
| SCHEMBL5532213 | 0.82 | EDNRA (0.42) | EDNRAAGTR1EDNRB | |
| SCHEMBL4764397 | 0.79 | EDNRA (0.41) | EDNRAAGTR1EDNRB | |
| SCHEMBL5534071 | 0.79 | EDNRA (0.39) | EDNRAAGTR1EDNRB | |
| SCHEMBL4770986 | 0.79 | EDNRA (0.41) | EDNRAAGTR1EDNRB | |
| SCHEMBL4773398 | 0.79 | EDNRA (0.41) | EDNRAAGTR1EDNRB | |
| SCHEMBL4771862 | 0.78 | EDNRA (0.41) | EDNRAAGTR1EDNRB | |
| SCHEMBL4764479 | 0.78 | EDNRA (0.43) | EDNRAAGTR1EDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109456-A2 | SUBSTITUTED BIPHENYL ISOXAZOLE SULFONAMIDES AS DUAL ANGIOTENSIN ENDOTHELIN RECEPTOR ANTAGONISTS | PHARMACOPEIA, INC. (US) | 2007-09-27 | — | — | WO | disclosed |