Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 9/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4940694 | 0.80 | GRM2 (0.69) | GRM2 | |
| SCHEMBL4944960 | 0.77 | GRM2 (0.60) | GRM2 | |
| SCHEMBL4945443 | 0.76 | GRM2 (0.78) | GRM2 | |
| SCHEMBL17176132 | 0.75 | GRM2 (0.75) | GRM2 | |
| SCHEMBL4945419 | 0.75 | GRM2 (1.00) | GRM2 | |
| SCHEMBL4943238 | 0.75 | GRM2 (0.74) | GRM2 | |
| SCHEMBL4944421 | 0.74 | GRM2 (0.74) | GRM2 | |
| SCHEMBL4940910 | 0.74 | GRM2 (0.77) | GRM2 | |
| SCHEMBL4942729 | 0.74 | GRM2 (0.76) | GRM2 | |
| SCHEMBL4946432 | 0.74 | GRM2 (0.77) | GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1773774-A2 | HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | Merck & Co., Inc. (US) | 2007-04-18 | — | — | EP | claimed |
| WO-2006014918-A2 | HETEROCYCLIC ACETOPHENONE POTENTIATORS OF METABOTROPIC GLUTAMATE RECEPTORS | MERCK & CO., INC. (US) | 2006-02-09 | — | — | WO | claimed |