SCHEMBL5320830

SCHEMBL5320830

Cc1ccc(C(=O)NC2CCNC2=O)cc1-n1cnc(OCc2ccc(F)cc2F)c(Cl)c1=O

nearest known ligand 0.69

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 16/20 0.69
MAPK11 Q15759 4/20 0.69
ROCK2 O75116 1/20 0.44
MAPK12 P53778 1/20 0.44
STRADA Q7RTN6 1/20 0.44
HTR6 P50406 1/20 0.41
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
DGAT2 Q96PD7 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9906481 0.88 MAPK14 (0.68) MAPK14MAPK11ROCK2MAPK12STRADA
SCHEMBL2853787 0.85 MAPK14 (0.69) MAPK14MAPK11ROCK2MAPK12STRADA
SCHEMBL13287495 0.85 MAPK14 (0.69) MAPK14MAPK11ROCK2MAPK12STRADA
SCHEMBL2853790 0.85 MAPK14 (0.69) MAPK14MAPK11ROCK2MAPK12STRADA
SCHEMBL5338798 0.85 MAPK14 (0.73) MAPK14MAPK11ROCK2MAPK12STRADA
SCHEMBL2851673 0.85 MAPK14 (0.68) MAPK14MAPK11ROCK2MAPK12STRADA
SCHEMBL2851670 0.85 MAPK14 (0.68) MAPK14MAPK11ROCK2MAPK12STRADA
SCHEMBL9906464 0.85 MAPK14 (0.70) MAPK14MAPK11ROCK2MAPK12STRADA
SCHEMBL9906463 0.85 MAPK14 (0.70) MAPK14MAPK11ROCK2MAPK12STRADA
SCHEMBL9906462 0.85 MAPK14 (0.70) MAPK14MAPK11ROCK2MAPK12STRADA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20040027521-A1 Liquid crystal cell with compensator layer and process EASTMAN KODAK COMPANY 2004-02-12 US claimed
US-20040027520-A1 Multilayer optical compensator, liquid crystal display, and process EASTMAN KODAK COMPANY 2004-02-12 US claimed
WO-2007081901-A2 PYRIMIDINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS THE SCRIPPS RESEARCH INSTITUTE (US) 2007-07-19 WO disclosed
WO-2007081901-A2 PYRIMIDINONE DERIVATIVES AS PROTEIN KINASE INHIBITORS THE SCRIPPS RESEARCH INSTITUTE (US) 2007-07-19 WO disclosed
US-20070153178-A1 Optical films having reverse dispersion EASTMAN KODAK COMPANY 2007-07-05 US disclosed
US-20060110549-A1 Cover sheet comprising tie layer for polarizer and method of manufacturing the same EASTMAN KODAK COMPANY 2006-05-25 US disclosed