Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 12/20 | 0.56 |
| ▸ | CDC7 | O00311 | 10/20 | 0.56 |
| ▸ | CDK2 | P24941 | 4/20 | 0.56 |
| ▸ | GSK3B | P49841 | 4/20 | 0.56 |
| ▸ | CDK1 | P06493 | 3/20 | 0.56 |
| ▸ | TAOK1 | Q7L7X3 | 3/20 | 0.56 |
| ▸ | CDK9 | P50750 | 3/20 | 0.56 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.56 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.56 |
| ▸ | IKBKB | O14920 | 1/20 | 0.56 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.56 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.56 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.56 |
| ▸ | PRKCB | P05771 | 1/20 | 0.56 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.56 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.56 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.56 |
| ▸ | PLK4 | O00444 | 2/20 | 0.48 |
| ▸ | MAPK13 | O15264 | 2/20 | 0.48 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5492858 | 0.99 | JAK2 (0.55) | JAK2CDC7CDK2GSK3BCDK1 | |
| SCHEMBL4187469 | 0.81 | JAK2 (0.58) | JAK2CDC7CDK2GSK3BCDK1 | |
| SCHEMBL4179435 | 0.78 | CDC7 (0.84) | JAK2CDC7CDK2GSK3BCDK1 | |
| SCHEMBL12095138 | 0.76 | CDC7 (0.82) | JAK2CDC7CDK2GSK3BCDK1 | |
| SCHEMBL4190464 | 0.74 | CDC7 (0.60) | JAK2CDC7CDK2GSK3BCDK1 | |
| SCHEMBL4194947 | 0.73 | CDC7 (0.58) | JAK2CDC7CDK2GSK3BCDK1 | |
| SCHEMBL12095032 | 0.73 | CDC7 (0.83) | JAK2CDC7CDK2GSK3BCDK1 | |
| SCHEMBL4188484 | 0.73 | JAK2 (0.83) | JAK2CDC7CDK2GSK3BCDK1 | |
| SCHEMBL4190177 | 0.73 | JAK2 (0.63) | JAK2CDC7CDK2GSK3BCDK1 | |
| SCHEMBL1133473 | 0.73 | JAK2 (0.56) | JAK2CDC7CDK2GSK3BCDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007096334-A1 | PYRROLOPYRROLONES ACTIVE AS KINASE INHIBITORS | PFIZER ITALIA SRL (IT) | 2007-08-30 | — | — | WO | disclosed |