Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR4 | Q5NUL3 | 7/20 | 0.41 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.41 |
| ▸ | SCN5A | Q14524 | 2/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 3/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.38 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.38 |
| ▸ | SLC16A1 | P53985 | 1/20 | 0.38 |
| ▸ | MCTS1 | Q9ULC4 | 1/20 | 0.38 |
| ▸ | GCGR | P47871 | 2/20 | 0.38 |
| ▸ | RORC | P51449 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.37 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5317632 | 0.95 | SLC22A12 (0.42) | FFAR4FFAR1SCN5ACYP2C9SLC22A12 | |
| SCHEMBL5316023 | 0.92 | PPARG (0.46) | FFAR4FFAR1SCN5ACYP2C9SLC22A12 | |
| SCHEMBL5317096 | 0.91 | AKR1B1 (0.43) | FFAR4FFAR1CYP2C9SLC22A12CYP3A4 | |
| SCHEMBL5269646 | 0.90 | F2RL3 (0.39) | SCN5ACYP2C9TP53CYP3A4 | |
| SCHEMBL5318163 | 0.90 | AKR1B1 (0.46) | CYP2C9SLC22A12TP53CYP3A4SLC16A3 | |
| SCHEMBL5339999 | 0.89 | F2RL3 (0.38) | SCN5ACYP2C9TP53CYP3A4 | |
| SCHEMBL5343398 | 0.88 | F2RL3 (0.38) | SCN5ACYP2C9TP53CYP3A4 | |
| SCHEMBL5319971 | 0.88 | F2RL3 (0.40) | CYP2C9TP53CYP3A4SLC16A3SLC16A1 | |
| SCHEMBL5323485 | 0.87 | FFAR4 (0.42) | FFAR4FFAR1SCN5ACYP2C9SLC22A12 | |
| SCHEMBL5319646 | 0.87 | PPARG (0.49) | CYP2C9SLC22A12CYP3A4SLC16A3SLC16A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2502624-A1 | Lonidamine analogues and their use in male contraception and cancer treatment | THE UNIVERSITY OF KANSAS (US) | 2012-09-26 | — | — | EP | claimed |
| EP-1786424-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | The University of Kansas (US) | 2007-05-23 | — | — | EP | claimed |
| WO-2006023704-A2 | LONIDAMINE ANALOGUES AND THEIR USE IN MALE CONTRACEPTION AND CANCER TREATMENT | UNIVERSITY OF KANSAS (US) | 2006-03-02 | — | — | WO | claimed |