Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN11 | Q06124 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | BCR | P11274 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.38 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | BLK | P51451 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.37 |
| ▸ | ATR | Q13535 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.36 |
| ▸ | ELANE | P08246 | 1/20 | 0.36 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.36 |
| ▸ | CKS1B | P61024 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL416107 | 0.88 | PTPN11 (0.43) | PTPN11CCNE2CCNE1CDK2GSK3B | |
| SCHEMBL415602 | 0.87 | CDK8 (0.41) | PTPN11ABL1PDGFRBBCRPDGFRA | |
| SCHEMBL878761 | 0.85 | PTPN11 (0.43) | PTPN11AAK1ALDH1A1MAPK10ELANE | |
| SCHEMBL856246 | 0.84 | PTPN11 (0.42) | PTPN11ABL1BCRALDH1A1ELANE | |
| SCHEMBL5322311 | 0.77 | PTPN11 (0.42) | PTPN11BTKDYRK1AALDH1A1CKS1B | |
| SCHEMBL856728 | 0.75 | NAMPT (0.41) | KDRNAMPT | |
| SCHEMBL856203 | 0.74 | ALK (0.40) | PTPN11DYRK1A | |
| SCHEMBL17939505 | 0.72 | BRD4 (0.52) | PTPN11BTK | |
| SCHEMBL10293196 | 0.72 | ALK (0.39) | PTPN11ALDH1A1CKS1BSKP2 | |
| SCHEMBL856210 | 0.70 | CYP1A2 (0.40) | PTPN11ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007002325-A1 | PYRROLO[2,3-B] PYRIDINE DERIVATIVES AS PROTEIN KINASE INHIBITORS | PLEXXIKON, INC. (US) | 2007-01-04 | — | — | WO | disclosed |