Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
| ▸ | JAK3 | P52333 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5322185 | 0.94 | PDE4B (0.53) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL5320584 | 0.93 | PDE4B (0.53) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL5319139 | 0.92 | PDE4B (0.51) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL5319163 | 0.89 | PDE4B (0.73) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL8235876 | 0.88 | PDE4B (0.57) | PDE4BCSF1RMAPT | |
| Hydrochloric Acid SCHEMBL5326547 | 0.87 | PDE4B (0.57) | PDE4BCSF1RMAPT | |
| SCHEMBL5318637 | 0.87 | PDE4B (0.50) | PDE4BCSF1RJAK2 | |
| SCHEMBL5318638 | 0.85 | PDE4B (0.48) | PDE4BCSF1RPDE4APDE4CPDE4D | |
| SCHEMBL4626888 | 0.82 | PDE4B (0.60) | PDE4BCSF1RMAPT | |
| SCHEMBL13593043 | 0.81 | PDE4B (0.59) | PDE4BCSF1RPDE4APDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007107499-A1 | QUINOLINE DERIVATIVES USEFUL AS PDE4 INHIBITORS | GLAXO GROUP LIMITED (GB) | 2007-09-27 | — | — | WO | claimed |