Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.91 |
| ▸ | PDE4A | P27815 | 11/20 | 0.91 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.91 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4046613 | 0.96 | PDE4B (1.00) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL24256423 | 0.85 | PDE4B (0.79) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4047975 | 0.84 | PDE4B (0.78) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4054018 | 0.84 | PDE4B (1.00) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4046251 | 0.84 | PDE4B (0.61) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4052296 | 0.83 | PDE4B (1.00) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4049052 | 0.82 | PDE4B (0.74) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4047905 | 0.81 | PDE4B (1.00) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL4046259 | 0.81 | PDE4B (1.00) | PDE4BPDE4APDE4DKDM4EALDH1A1 | |
| SCHEMBL5242434 | 0.80 | PDE4B (0.74) | PDE4BPDE4APDE4DKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1819710-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | Laboratorios Almirall, S.A. (ES) | 2007-08-22 | — | — | EP | disclosed |
| WO-2006058724-A1 | NEW PYRIDOTHIENOPYRIMIDINE DERIVATIVES | LABORATORIOS ALMIRALL, S.A. (ES) | 2006-06-08 | — | — | WO | disclosed |