Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TOP1 | P11387 | 15/20 | 0.73 |
| ▸ | MEN1 | O00255 | 3/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.69 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.69 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.69 |
| ▸ | HBB | P68871 | 2/20 | 0.69 |
| ▸ | CASP1 | P29466 | 1/20 | 0.69 |
| ▸ | CASP7 | P55210 | 1/20 | 0.69 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.66 |
| ▸ | HDAC4 | P56524 | 4/20 | 0.66 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.66 |
| ▸ | HDAC7 | Q8WUI4 | 4/20 | 0.66 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.66 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.66 |
| ▸ | HDAC11 | Q96DB2 | 4/20 | 0.66 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.66 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.66 |
| ▸ | HDAC9 | Q9UKV0 | 4/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28292759 | 0.98 | TOP1 (0.76) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL28117060 | 0.95 | TOP1 (0.77) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL28445420 | 0.95 | TOP1 (0.68) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL28291366 | 0.94 | TOP1 (0.79) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL8506572 | 0.91 | TOP1 (0.79) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5322751 | 0.90 | TOP1 (0.71) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5323885 | 0.90 | TOP1 (0.71) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL5318924 | 0.90 | TOP1 (0.71) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL7008598 | 0.90 | TOP1 (0.75) | TOP1MEN1KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL29229512 | 0.89 | TOP1 (0.81) | TOP1MEN1KMT2ASMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007095389-A2 | TREATMENT OF HYPERPROLIFERATIVE DISEASES WITH CAMPTOTHECINE N-OXIDE AND ANALOGS | NOVACEA, INC. (US) | 2007-08-23 | — | — | WO | claimed |
| WO-2007095389-A2 | TREATMENT OF HYPERPROLIFERATIVE DISEASES WITH CAMPTOTHECINE N-OXIDE AND ANALOGS | NOVACEA, INC. (US) | 2007-08-23 | — | — | WO | disclosed |