Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 14/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 14/20 | 0.68 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.68 |
| ▸ | PI4KB | Q9UBF8 | 5/20 | 0.62 |
| ▸ | PIK3CA | P42336 | 10/20 | 0.60 |
| ▸ | PIK3CB | P42338 | 8/20 | 0.60 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.54 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.54 |
| ▸ | PI4KA | P42356 | 1/20 | 0.54 |
| ▸ | PRKDC | P78527 | 1/20 | 0.54 |
| ▸ | PIK3C2G | O75747 | 2/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48667 | 0.90 | PIK3CD (0.60) | PIK3CDPIK3CGPIK3C3PI4KBPIK3CA | |
| SCHEMBL49041 | 0.86 | PIK3CD (0.66) | PIK3CDPIK3CGPIK3C3PI4KBPIK3CA | |
| SCHEMBL5321637 | 0.85 | PIK3CD (0.51) | PIK3CDPIK3CGPIK3C3PI4KBPIK3CA | |
| SCHEMBL49279 | 0.85 | PIK3CG (0.56) | PIK3CDPIK3CGPIK3C3PI4KBPIK3CA | |
| SCHEMBL48786 | 0.84 | PIK3CD (0.54) | PIK3CDPIK3CGPIK3C3PI4KBPIK3CA | |
| SCHEMBL48392 | 0.84 | PIK3CG (0.83) | PIK3CDPIK3CGPIK3C3PI4KBPIK3CA | |
| SCHEMBL49493 | 0.84 | PIK3CG (0.62) | PIK3CDPIK3CGPIK3C3PI4KBPIK3CA | |
| SCHEMBL48896 | 0.84 | PIK3CD (0.62) | PIK3CDPIK3CGPIK3C3PI4KBPIK3CA | |
| SCHEMBL48762 | 0.83 | PIK3CD (0.67) | PIK3CDPIK3CGPIK3C3PI4KBPIK3CA | |
| SCHEMBL48988 | 0.82 | PIK3CD (0.61) | PIK3CDPIK3CGPIK3C3PI4KBPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007129005-A1 | AMINOACID DERIVATIVES OF THIAZOLES AS INHIBITORS OF PI3 KINASE | CHROMA THERAPEUTICS LTD. (GB) | 2007-11-15 | — | — | WO | disclosed |