Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | DRD1 | P21728 | 1/20 | 0.34 |
| ▸ | HRH2 | P25021 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SCN1A | P35498 | 1/20 | 0.34 |
| ▸ | THPO | P40225 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1837522 | 0.81 | — | — | |
| SCHEMBL29078535 | 0.81 | CYP3A4 (0.42) | CYP3A4TSHRABCB11LMNACYP1A2 | |
| SCHEMBL15579618 | 0.81 | CYP3A4 (0.42) | CYP3A4TSHRABCB11LMNACYP1A2 | |
| SCHEMBL1041208 | 0.81 | CYP3A4 (0.39) | CYP3A4TSHRABCB11LMNACYP1A2 | |
| SCHEMBL30152476 | 0.81 | CYP3A4 (0.42) | CYP3A4TSHRABCB11LMNACYP1A2 | |
| SCHEMBL3706334 | 0.80 | CYP3A4 (0.34) | CYP3A4TSHRABCB11LMNACYP1A2 | |
| Lithium SCHEMBL5448277 | 0.79 | CYP3A4 (0.41) | CYP3A4TSHRABCB11LMNACYP1A2 | |
| SCHEMBL994460 | 0.78 | EPHX1 (0.38) | CYP3A4TSHRABCB11LMNACYP1A2 | |
| SCHEMBL30152586 | 0.77 | CYP3A4 (0.39) | CYP3A4TSHRABCB11LMNACYP1A2 | |
| SCHEMBL22117116 | 0.75 | CYP2D6 (0.32) | CYP3A4TSHRABCB11LMNACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007103719-A2 | MODULATORS OF 11-β HYDROXYL STEROID DEHYDROGENASE TYPE 1, PHARMACEUTICAL COMPOSITIONS THEREOF, AND METHODS OF USING THE SAME | INCYTE CORPORATION (US) | 2007-09-13 | — | — | WO | disclosed |