Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 1/20 | 0.39 |
| ▸ | CMA1 | P23946 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.39 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.37 |
| ▸ | RORC | P51449 | 1/20 | 0.37 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5201573 | 1.00 | MEN1 (0.49) | MEN1KMT2AALDH1A1MMP2CHRM1 | |
| SCHEMBL6296895 | 1.00 | MEN1 (0.49) | MEN1KMT2AALDH1A1MMP2CHRM1 | |
| SCHEMBL6296896 | 1.00 | MEN1 (0.49) | MEN1KMT2AALDH1A1MMP2CHRM1 | |
| SCHEMBL5201579 | 1.00 | MEN1 (0.49) | MEN1KMT2AALDH1A1MMP2CHRM1 | |
| SCHEMBL5200881 | 0.88 | CNR1 (0.41) | MEN1KMT2AAKR1C3 | |
| SCHEMBL5201586 | 0.88 | CNR1 (0.41) | MEN1KMT2AAKR1C3 | |
| SCHEMBL5201582 | 0.88 | CNR1 (0.41) | MEN1KMT2AAKR1C3 | |
| SCHEMBL5200884 | 0.88 | CNR1 (0.41) | MEN1KMT2AAKR1C3 | |
| SCHEMBL5201963 | 0.87 | MEN1 (0.40) | MEN1KMT2AALDH1A1MMP2CHRM1 | |
| SCHEMBL5201960 | 0.87 | MEN1 (0.40) | MEN1KMT2AALDH1A1MMP2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1389200-A4 | SUBSTITUTED N-ARYLSULFONYL-PROLINE DERIVATIVES AS POTENT CELL ADHESION INHIBITORS | MERCK & CO INC (US) | 2007-03-28 | — | — | EP | disclosed |
| EP-1389200-A1 | SUBSTITUTED N-ARYLSULFONYL-PROLINE DERIVATIVES AS POTENT CELL ADHESION INHIBITORS | Merck & Co., Inc. (US) | 2004-02-18 | — | — | EP | disclosed |
| WO-2002074761-A1 | SUBSTITUTED N-ARYLSULFONYL-PROLINE DERIVATIVES AS POTENT CELL ADHESION INHIBITORS | MERCK & CO., INC. (US) | 2002-09-26 | — | — | WO | disclosed |