Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.60 |
| ▸ | RET | P07949 | 4/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.47 |
| ▸ | FLT1 | P17948 | 1/20 | 0.47 |
| ▸ | FLT4 | P35916 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5321249 | 0.89 | KDR (0.61) | KDRRETCSF1RKITPDGFRA | |
| SCHEMBL5323283 | 0.87 | KDR (0.60) | KDRRETCSF1RKITPDGFRA | |
| SCHEMBL5321155 | 0.86 | KDR (0.65) | KDRRETCSF1RKITPDGFRA | |
| SCHEMBL5330296 | 0.85 | KDR (0.56) | KDRRETCSF1RKITPDGFRA | |
| SCHEMBL5323249 | 0.83 | KDR (0.55) | KDRRETCSF1RKITPDGFRA | |
| SCHEMBL2452874 | 0.83 | KDR (0.61) | KDRRETCSF1RKITPDGFRA | |
| SCHEMBL2452878 | 0.83 | KDR (0.61) | KDRRETCSF1RKITPDGFRA | |
| SCHEMBL5328551 | 0.75 | KDR (1.00) | KDRRETCSF1RKITPDGFRA | |
| SCHEMBL2454393 | 0.75 | KDR (1.00) | KDRRETCSF1RKITPDGFRA | |
| SCHEMBL2450862 | 0.75 | KDR (0.61) | KDRRETCSF1RKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007109783-A2 | SUBSTITUTED PYRIMIDINE KINASE INHIBITORS | JANSSEN PHARMACEUTICA, N.V. (BE) | 2007-09-27 | — | — | WO | claimed |