Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | AHR | P35869 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HK1 | P19367 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GALK1 | P51570 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28279803 | 0.83 | GAA (0.46) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL6954505 | 0.80 | MAPT (0.50) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL30059612 | 0.75 | MAPT (0.53) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL30943790 | 0.73 | IDO1 (0.46) | TSHRPNMT | |
| SCHEMBL12841651 | 0.73 | CREBBP (0.39) | MAPTGAABRD4CREBBPTSHR | |
| SCHEMBL11207070 | 0.71 | MAPT (0.50) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL1736809 | 0.71 | CREBBP (0.55) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL31517110 | 0.71 | MAPT (0.55) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL2781001 | 0.71 | MAPT (0.55) | MAPTGAAARBRD4CREBBP | |
| SCHEMBL12837999 | 0.71 | CREBBP (0.55) | MAPTGAAARBRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007146230-A2 | NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS | MERCK & CO., INC. (US) | 2007-12-21 | — | — | WO | disclosed |