Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 2/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.45 |
| ▸ | CDC25B | P30305 | 5/20 | 0.45 |
| ▸ | PTPRC | P08575 | 5/20 | 0.45 |
| ▸ | PTPRF | P10586 | 1/20 | 0.45 |
| ▸ | IDO1 | P14902 | 4/20 | 0.44 |
| ▸ | MAOA | P21397 | 2/20 | 0.44 |
| ▸ | MAOB | P27338 | 2/20 | 0.44 |
| ▸ | SNCA | P37840 | 2/20 | 0.44 |
| ▸ | AKT1 | P31749 | 1/20 | 0.44 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.44 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.44 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.44 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.44 |
| ▸ | EHMT1 | Q9H9B1 | 1/20 | 0.44 |
| ▸ | CDC25A | P30304 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9286666 | 0.88 | BACE1 (0.60) | BACE1PTPN1CDC25BPTPRCPTPRF | |
| SCHEMBL1708066 | 0.88 | BACE1 (0.60) | BACE1PTPN1CDC25BPTPRCPTPRF | |
| SCHEMBL5886591 | 0.83 | ABCG2 (0.39) | BACE1PTPN1CDC25BPTPRCPTPRF | |
| SCHEMBL10354666 | 0.83 | ABCG2 (0.39) | BACE1PTPN1CDC25BPTPRCPTPRF | |
| SCHEMBL9118090 | 0.80 | ABCG2 (0.38) | PTPN1CDC25BPTPRCPTPRFIDO1 | |
| SCHEMBL7119051 | 0.79 | CDC25B (0.53) | BACE1PTPN1CDC25BPTPRCPTPRF | |
| SCHEMBL8596446 | 0.76 | PTPN1 (0.64) | BACE1PTPN1CDC25BPTPRCPTPRF | |
| SCHEMBL2029502 | 0.75 | MAPT (0.38) | BACE1PTPN1CDC25BPTPRCPTPRF | |
| SCHEMBL9811026 | 0.75 | PTPRC (0.38) | BACE1PTPN1CDC25BPTPRCPTPRF | |
| SCHEMBL9810973 | 0.75 | PTPN1 (0.38) | BACE1PTPN1CDC25BPTPRCPTPRF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070249653-A1 | Tetracyclic benzamide derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-10-25 | — | — | US | disclosed |
| WO-2007117289-A2 | METHODS FOR TREATING OR PREVENTING ERECTILE DYSFUNCTION OR URINARY INCONTINENCE | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-10-18 | — | — | WO | disclosed |
| US-7217709-B2 | Tetracyclic benzamide derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION (US) | 2007-05-15 | — | — | US | disclosed |
| EP-1603567-A4 | TETRACYCLIC BENZAMIDE DERIVATIVES AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORP (US) | 2006-10-18 | — | — | EP | disclosed |
| EP-1603567-A2 | TETRACYCLIC BENZAMIDE DERIVATIVES AND METHODS OF USE THEREOF | Inotek Pharmaceuticals Corporation (US) | 2005-12-14 | — | — | EP | disclosed |
| WO-2005009398-A2 | TETRACYCLIC BENZAMIDE DERIVATIVES AND METHODS OF USE THEREOF | INOTEK PHARMACEUTICALS CORPORATION (US) | 2005-02-03 | — | — | WO | disclosed |
| US-20040229895-A1 | Tetracyclic benzamide derivatives and methods of use thereof | INOTEK PHARMACEUTICALS CORPORATION | 2004-11-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070249653-A1 | Tetracyclic benzamide derivatives and methods of use thereof | TBC1D5, TBC1D15, BAD | BACE1 3583/4885PTPN1 3851/4885CDC25B 1879/4885 |
| US-20040229895-A1 | Tetracyclic benzamide derivatives and methods of use thereof | TBC1D5, TBC1D15, BAD | BACE1 3583/4885PTPN1 3851/4885CDC25B 1879/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.