Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | TSHR | P16473 | 3/20 | 0.61 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | TP53 | P04637 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.58 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | ATM | Q13315 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5327292 | 1.00 | POLB (0.67) | POLBCYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL5328274 | 0.89 | TP53 (0.75) | POLBCYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL5328282 | 0.89 | TP53 (0.75) | POLBCYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL30864907 | 0.88 | PTK2 (0.67) | POLBCYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL30864910 | 0.88 | PTK2 (0.67) | POLBCYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL30864917 | 0.85 | PTK2 (0.67) | POLBCYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL30864919 | 0.85 | PTK2 (0.67) | POLBCYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL30864918 | 0.85 | PTK2 (0.67) | POLBCYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL30864913 | 0.82 | GAA (0.67) | POLBCYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL30864901 | 0.82 | PTK2 (0.63) | POLBCYP3A4CYP2D6CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |
| WO-2007047394-A2 | THIOTRIAZOLYL DERIVATIVES | EPIX DELAWARE, INC. (US) | 2007-04-26 | — | — | WO | disclosed |